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Researching and Writing

My Publications


Assessing the role of pleural fluid in current cancer diagnostic pathway

Catherine Doig, Christopher Butter, Nikolaos Hadjisavvas, Sujoy Saikia, Ali Fawzi, Madeleine Hewish, Shashank Sharma

European Respiratory Journal 2020 56: 2923; DOI: 10.1183/13993003.congress-2020.2923


Pleural fluid will yield diagnosis in approximately 60% of malignant effusions. We aim to review the use of thoracentesis in a NHS District General Hospital, evaluating its role in diagnosis and ability to guide oncological therapy with the help of immunochemistry analysis.

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Cyclophosphamide for the treatment of inflammation-driven fibrotic interstitial lung disease

Shashank Sharma, Winston Banya, Elizabeth Renzoni, Athol Wells, Maher Toby
European Respiratory Journal 2014 44: P722; DOI:

Aim:Interstitial lung disease (ILD) encompasses a heterogeneous group of disorders with different histological subtypes, pathobiology, prognosis and response to treatment. There is paucity of randomised controlled trials to guide treatment in majority of ILDs, however, cyclophosphamide is widely used in the treatment of inflammatory driven ILD. We sought to retrospectively assess treatment response to cyclophosphamide in our cohort of ILD patients.

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Role of bronchoscopy in patients with haemoptysis and a normal CT scan

Shashank Sharma, Arash Poorghobad, Michael Wood
European Respiratory Journal 2012 40: P4408; DOI:

Aims and Objectives: To investigate the merits of conducting bronchoscopies in patients with haemoptysis and normal or non-diagnostic CT scan.

Methods: Using the in-hospital bronchoscopy reporting tool, a retrospective analysis was carried out of the bronchoscopies performed on patients with haemoptysis but non-diagnostic CT scan.

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Mesothelioma diagnosis in a district general hospital

Shashank Sharma, Katie Wimble, Behdad Shambayati, Michael Wood
European Respiratory Journal 2012 40: P1253; DOI:

Background: Malignant mesothelioma(MM) is a rare cancer with poor prognosis, posing a diagnostic challenge to respiratory physicians.

Aim: We analysed our current diagnostic process for MM to assess the diagnostic yield of different investigative modalities.

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Overnight oximetry as a screening tool for moderate or severe obstructive sleep apnoea

S. Sharma, J.C. Ratoff
European Respiratory Journal 2011 38: p3922; DOI:

Background: With increasing prevalence of obesity, the burden of obstructive sleep apnoea (OSA) on public health services will increase. It is estimated that 4% of middle-aged men have significant OSA. Current SIGN guidelines for OSA recommend treatment with CPAP if the apnoea hypopnoea index (AHI)≥ 15/hr or oxygen desaturation index (ODI) ≥10/hr. It would be of both clinical and economic benefit, if a simple test like overnight oximetry could be used to screen the patients for moderate or severe OSA.

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The use of perioperative intravenous sildenafil in patients with mitral valve disease and co-existent pulmonary hypertension during cardiac surgery

B.P. Madden, S. Sharma, E. Holden, Y. Looney, S.N. Fletcher, A. Sheth
European Respiratory Journal 2011 38: p2381; DOI:


Introduction: Patients who have mitral valve (MV) disease with associated pulmonary hypertension (PH) may develop acute rises in pulmonary vascular resistance (PVR) perioperatively.Such pulmonary hypertensive crises may significantly increase perioperative morbidity and mortality. Although there is limited experience with agents to reduce the PVR, their use may be associated with systemic hypotension.

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Management of parapneumonic effusion - Does the size of the chest drain matter?

S. Sharma, J. Kuah, A. Liju (London, United Kingdom)

Source: International Congress 2014 – Resistance, bacteriological profile and comorbidities in respiratory infections

Session: Resistance, bacteriological profile and comorbidities in respiratory infections
Session type: Thematic Poster Session
Number: 2533

Disease area: Respiratory infections

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19 - Pembrolizumab-induced subacute sensory ataxia

Author A.J.S. Furness,  J. Coebergh,  M. Wood,  M. Irvine-Sellars,  S. Saikia,  S. Sharma,  B. McBride,  C. Johnson,  M. Teoh, 

F. Cockroft,  S. Wing,  P. Murray,  M. Hewish


P62 Oxygen desaturation index for diagnosing obstructive sleep apnoea in patients with morbid obesity

Authors A Fawzi, H Basheer, M Patel, S Sharma  (St Peter’s Hospital, London, UK

First published November 15, 2017.


A comparative evaluation of the efficacy of inhaled beclomethasone dipropionate, budesonide and fluticasone propionate in the management of bronchial asthma

Authors: U Parakh, K Gupta, S Sharma, S N Gaur

First published January 2004


Stroke due to Thromboembolism from Congenital Aneurysm of Ventricular Septum

Shashank Sharma, Ajit Thomas, Aram Baghomian, Nick Waterfield


We describe the case of a 46-year-old female who presented with recurrent episodes of cerebrovascular events. She had an unremarkable family history and no risk factors for stroke, apart from smoking. A transthoracic echocardiogram with 'bubble' contrast was normal. However transoesophageal echocardiography demonstrated an aneurysm of the membranous part of the ventricular septum, representing the likely source of thrombo-embolisation. This case highlights the need for a systematic and rigorous approach to the investigation of young patients with stroke.

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